Transient vs Permanent Congenital Hypothyroidism: Does Thyroid Volume Tell the Tale?
Authors' conclusion
Thyroid volume ≥2.5 mL or ≤0.36 mL was seen only in permanent CH, potentially avoiding the need for a trial off levothyroxine. Using both TSH level and thyroid volume provides increased sensitivity and specificity for differentiating between permanent and transient CH.
Study context
- Population
- Patients with congenital hypothyroidism (CH) with eutopic thyroids, 1/2005–12/2019
- Exposure
- Transient vs permanent congenital hypothyroidism
- Outcome
- Thyroid volume measured by US to distinguish transient from permanent CH
Main finding
As reported in the abstract
Thyroid volume
Observational data: associations, not effects.
Further findings
Thyroid-stimulating hormone (TSH) levels
- Significant difference in TSH levels between the 2 groups
Combined TSH at diagnosis ≥200 mIU/L and thyroid volume ≤0.6 mL or ≥2.5 mL for differentiating transient vs permanent CH
- Sensitivity
- 78.4%
- Specificity
- 85.7%
Original publication
Transient vs Permanent Congenital Hypothyroidism: Does Thyroid Volume Tell the Tale? Endocr Pract. Published 3 June 2025. doi:10.
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