Permanent vs Transient Congenital Hypothyroidism in Chinese Children: Physical Growth and Predictive Nomogram
Authors' conclusion
TSH at NBS and L-T4 doses during treatment can be used to distinguish between PCH and TCH early in life, and the predictive efficacy can be improved using multivariable models with a visualized nomogram. At 3 years of age, patients with TCH and PCH showed similar growth.
Study context
- Population
- Chinese children with transient congenital hypothyroidism (TCH) or permanent congenital hypothyroidism (PCH)
- Exposure
- Transient vs permanent congenital hypothyroidism
- Outcome
- Prediction of TCH vs PCH (AUC)
Main finding
As reported in the abstract
- AUC of initial thyroid-stimulating hormone (TSH)
- 0.698
- AUC of LT4 dose at 1 year of age
- 0.71
- AUC of LT4 dose at 2 years of age
- 0.879
- AUC of multivariate model at 1 year of age
- 0.752
- AUC of multivariate model at 2 years of age
- 0.922
Observational data: associations, not effects.
Further findings
Initial TSH at newborn screening
- Lower initial TSH in TCH than PCH
LT4 dose over time
- LT4 dose gradually decreased with age in TCH but not in PCH
Growth
- Growth did not differ between TCH and PCH
Height and weight z-scores by sex · 1 year of age
- Girls with CH had higher height and weight z-scores than boys with CH
Original publication
Permanent vs Transient Congenital Hypothyroidism in Chinese Children: Physical Growth and Predictive Nomogram. J Clin Endocrinol Metab. Published 16 December 2023. doi:10.
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