Reduction in Pappalysin-2 Levels and Lower IGF-I Bioavailability in Female Adolescents With Anorexia Nervosa
Authors' conclusion
The reduction of PAPP-A2 in patients with AN may be involved in a decline in IGFBP cleavage, which could underlie the decrease in IGF-I bioavailability that is influenced by nutritional status and amenorrhea.
Study context
- Population
- Female adolescents with anorexia nervosa (AN) at diagnosis
- Participants
- 68 vs 62
- Comparison
- Female adolescents with AN vs matched controls
- ANn = 68
- Controlsn = 62reference
- Outcome
- Serum levels of PAPP-As and STCs in relationship with classical IGF axis parameters
- Follow-up
- At diagnosis
Methodological detailssex- and age-matched controls
- Sex- and age-matched controls
Main finding
As reported in the abstract
IGF axis parameters, PAPP-As and STCs
- AN had lower total and free IGF-I, total IGFBP-3, acid-labile subunit (ALS), insulin, PAPP-A2, stanniocalcins (STC-1) and STC-2 vs controls
- AN had higher IGF-II and IGFBP-2
- AN had decreased free/total IGF-I ratio and increased intact/total IGFBP-3 and −4 ratios
Observational data: associations, not effects.
Further findings
Associations with body mass index (BMI), weight loss and bone mineral density (BMD)
- BMI directly related to total IGF-I and intact IGFBP-3, inversely to IGFBP-2 and intact IGFBP-4
- Weight loss directly correlated with intact IGFBP-4, negatively with intact IGFBP-3, ALS, STC-2 and PAPP-A2
- BMD directly related to intact IGFBP-3, inversely to intact IGFBP-4 and PAPP-A2
Secondary amenorrhea
- Amenorrhea associated with lower total IGF-I and IGFBP-3 than menses
Original publication
Reduction in Pappalysin-2 Levels and Lower IGF-I Bioavailability in Female Adolescents With Anorexia Nervosa. J Clin Endocrinol Metab. Published 8 December 2023. doi:10.
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