Drivers of Patient and Caregiver Preferences for Growth Hormone Deficiency Treatments in France: A Discrete Choice Experiment
Authors' conclusion
Children with GHD and their caregivers prefer a less frequent injection schedule and lower injection pain. Both aspects of treatment modalities are important to consider in treatment decisions to alleviate the daily burden for GHD patients and their families and potentially enhance treatment adherence.
Study context
- Population
- French children and adolescents with growth hormone deficiency (GHD) and their caregiverspatients represented
- Participants
- 105 children
- Comparison
- Autonomous adolescents vs Nonautonomous adolescent/caregiver dyads vs Caregivers of nonautonomous children vs Autonomous children/caregiver dyads
- Outcome
- Drivers of preference and relative importance of GHD treatment modality attributes (frequency of administration, injection pain, dose setting, type of device, storage, device reusability)
Methodological detailsonline questionnaire, 12 choice tasks, pilot tested, multinomial logit model with random effects
- Online questionnaire
- 12 choice tasks
- Pilot tested
- Multinomial logit model with random effects
Main finding
As reported in the abstract
Relative importance of treatment attributes
- Frequency of administration and injection pain had the greatest influence on preferences, with similar importance
- Weekly administration significantly preferred over daily by all groups
- Choices also significantly influenced by type of device, dose setting and device reusability
Original publication
Drivers of Patient and Caregiver Preferences for Growth Hormone Deficiency Treatments in France: A Discrete Choice Experiment. Horm Res Paediatr. Published 29 November 2023. doi:10.
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