Fracture Risk in Patients with Anorexia Nervosa Over a 40-Year Period
Main finding · Any fractureResult — go to the resultAdjusted hazard ratio 1.46 95% CI 1.36–1.48Authors' conclusion
In conclusion, we found that AN was associated with a 46% increased risk of any fracture up to 40 years after diagnosis. We found no overall increased risk in males, but in both sexes we found a particularly high site-specific fracture risk in the spine and femur.
Study context
- Population
- Patients with anorexia nervosa (13,474 females, 940 males) diagnosed 1977–2018 in Denmark; median age 18.6 yearsmatched cohort
- Participants
- 14,414 patients
- Exposure
- Anorexia nervosa (AN) vs matched general-population comparison cohort
- ANn = 14,414
- Outcome
- Any fracture (overall fracture risk)
- Follow-up
- Up to 40 years; median 9.65 years
Methodological detailsDanish Health Care Registers, matched comparison cohort from the general population, Cox regression
- Danish Health Care Registers
- Matched comparison cohort from the general population
- Cox regression
Main finding
Any fracture
Adjusted hazard ratio
1.46
95% CI 1.36–1.48
ANvs Comparison
aHR 1.46 (95% CI 1.36–1.48)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Any fracture, females | 1.50 (1.43–1.57) | |
| Any fracture, males | 0.95 (0.82–1.1) | |
| Femur fracture, females | 4.06 (3.39–4.46) | |
| Spine fracture, females | 2.38 (2.00–2.84) | |
| Spine fracture, males | 2.31 (1.20–4.42) | |
| Any fracture, diagnosed 1977–1997 | 1.66 (1.52–1.81) | |
| Any fracture, diagnosed 1998–2018 | 1.40 (1.33–1.40) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
| Outcome | aHR (95% CI) |
|---|---|
| Femur fracture, malesEstimate outside its printed CI | 2.79 (1.45–2.37) |
Original publication
Fracture Risk in Patients with Anorexia Nervosa Over a 40-Year Period. J Bone Miner Res. Published 30 August 2023. doi:10.
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