Effects of teriparatide on hip structure and bone microarchitecture in women with anorexia nervosa: a placebo-controlled randomized trial
Authors' conclusion
Six months of TPT treatment in women with anorexia nervosa led to trends in improvements in bone structure.
Study context
- Population
- Women with anorexia nervosa and a T-score ≤ - 2.5
- Participants
- 21 women
- Comparison
- Teriparatide vs placebo for 6 months
- TPTn = 10
- Placebon = 11reference
- Primary endpoint
- Changes in trabecular and cortical bone microarchitecture (HR-pQCT) and hip structural analysis parameters (HSA program)
- Follow-up
- 6 months
Methodological detailsplacebo-controlled
- Placebo-controlled
Primary result
As reported in the abstract
IT cortical thickness increase after TPT (p = 0.075 vs. baseline); non-significant decrease in placebo
13%
IT buckling ratio decrease vs baseline in TPT
9%
IT buckling ratio increase in placebo (TPT vs placebo p = 0.076)
5%
Secondary outcomes
Bone turnover markers: osteocalcin and osteopontin · 6 months
- Osteocalcin increase in TPT (p = 0.01 vs. baseline)
- 216.4%
- Osteopontin increase in TPT (p = 0.03 vs. baseline)
- 68.6%
- No significant changes in osteocalcin or osteopontin in placebo
Original publication
Effects of teriparatide on hip structure and bone microarchitecture in women with anorexia nervosa: a placebo-controlled randomized trial. Osteoporos Int. Published 27 January 2026. doi:10.
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