Sex Differences in Phosphate Homeostasis: Females Excrete More Phosphate and Calcium After an Oral Phosphate Challenge
Authors' conclusion
Taken together, these data identify sex differences in acute phosphate homeostasis, specifically that females may mobilize and excrete endogenous sources of calcium and phosphate in response to oral phosphate compared to males. While high levels of dietary phosphate negatively impact bone, our results suggest that females may incur more risk from these diets.
Study context
- Population
- Adults 40–76 years with measured GFR >60 mL/min/1.73 m² and no clinically diagnosed cardiovascular disease (CVD), plus 14 young healthy adults; general communityplus 14 young healthy adults
- Participants
- 78 adults
- Exposure
- Females vs males
- Outcome
- Hormonal response, circulating mineral levels and urinary excretion after an oral phosphate challenge
Methodological detailsoral phosphate challenge
- Oral phosphate challenge
Main finding
As reported in the abstract
Response to oral phosphate challenge
Phosphate excretion, females vs males
∼1.9x more
Calcium excretion, females vs males, despite not consuming calcium
∼2.7x more
Observational data: associations, not effects.
Further findings
Young healthy adults
- Sex differences were recapitulated in healthy young adults
Correlates of excretion response
- Excretion response did not correlate to age, serum phosphate or estradiol levels
- Females with greater phosphate excretion had higher bone resorption markers relative to formation markers
Original publication
Sex Differences in Phosphate Homeostasis: Females Excrete More Phosphate and Calcium After an Oral Phosphate Challenge. J Clin Endocrinol Metab. Published 21 October 2022. doi:10.
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