Combined Arginine and Insulin Stimulation Elicits a Robust and Consistent Copeptin Response in Short Children
Authors' conclusion
Arginine and insulin appear to have an additive and consistent effect resulting in significant stimulation of copeptin secretion in children. The AITT may be a useful tool to evaluate for normal posterior pituitary function in this age-group, with potential implications for the evaluation of polyuria-polydipsia syndrome.
Study context
- Population
- Children aged 7–16 years undergoing GH stimulation testing with arginine-insulin tolerance test (AITT) for short stature or growth deceleration, tertiary referral center
- Participants
- 38 children
- Outcome
- Peak copeptin concentration
Methodological detailstertiary referral center
- Tertiary referral center
Main finding
As reported in the abstract
Serum copeptin concentration · 0, 60 and 90 min
Copeptin at 0 min (mean ± SD)
9.9 ± 5.0 pmol/L
Copeptin at 60 min (post-arginine; mean ± SD)
13.2 ± 5.8 pmol/L; p < 0.0001 vs. 0 min
Copeptin at 90 min (post-insulin; mean ± SD)
27.7 ± 14.2 pmol/L; p < 0.0001 vs. 0 and 60 min
Observational data: associations, not effects.
Further findings
- No significant correlation between copeptin concentrations and age, BMI, pubertal status, cortisol, GH or glucose concentrations
Original publication
Combined Arginine and Insulin Stimulation Elicits a Robust and Consistent Copeptin Response in Short Children. Horm Res Paediatr. Published 13 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →