Evaluation of cardiac structure, exercise capacity and electrocardiography parameters in children with partial and complete growth hormone deficiency and their changes with short term growth hormone replacement therapy
Authors' conclusion
This study showed that children with both partial and complete GHD had smaller cardiac structures and less exercise capacity compared to their healthy peers prior to GH treatment but this improved with 12 months of treatment. The cardiac trophic effect of GH, as well as the effect of increasing exercise capacity, is greater in those with complete GHD than in those with partial GHD.
Study context
- Population
- Children with GHD aged 9–14 years
- Participants
- 30 / 17 / 48
- Exposure
- Complete GHD vs partial GHD vs healthy peers; baseline vs 12 months of growth hormone (GH) treatment
- Complete GHDn = 30
- Partial GHDn = 17
- Healthy peersn = 48reference
- Outcome
- Left ventricular mass (LVM)
- Follow-up
- Before treatment and after 12 months of GH treatment
Methodological detailshealthy control comparison, 12-month GH treatment
- Healthy control comparison
- 12-month GH treatment
Main finding
As reported in the abstract
- Significant increase in left ventricular mass (LVM) with treatment in complete GHD
- p = 0.044
- LVM index significantly reduced with treatment in partial GHD
- p = 0.035
Observational data: associations, not effects.
Further findings
Exercise capacity in complete GHD after treatment · 12 months
- Max metabolic equivalent (METs) significantly increased
- P = 0.022
- VO2max significantly increased
- P = 0.015
- Exercise duration significantly increased
- P = 0.002
Electrocardiography (ECG): P wave and QTc dispersion
- Significant changes between groups were within physiological limits
Original publication
Evaluation of cardiac structure, exercise capacity and electrocardiography parameters in children with partial and complete growth hormone deficiency and their changes with short term growth hormone replacement therapy. Pituitary. Published 4 December 2022. doi:10.
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