Serum IGF-1 to IGFBP-3 Molar Ratio: A Promising Diagnostic Tool for Growth Hormone Deficiency in Children
Authors' conclusion
Our data suggest that the serum IGF-1/IGFBP-3 ratio is a useful marker for the diagnosis of GHD in children who do not have other disorders that may affect serum IGF-1 levels. Further large studies are needed to confirm the diagnostic utility of the serum IGF-1/IGFBP-3 ratio.
Study context
- Population
- Children with short stature, excluding known disorders affecting IGF-1 other than growth hormone deficiency (GHD); GHD vs non-GHD; GHD = growth rate <25th percentile over 1 year and peak growth hormone (GH) < 6.25 ng/mL on 2 GH stimulation tests64 GHD, 171 non-GHD · GHD 64 · vs non-GHD 171
- Participants
- 235 children
- Comparison
- Serum IGF-1/IGFBP-3 molar ratio, alone and combined with IGF-1 and IGFBP-3, for diagnosis of GHD
- Outcome
- Sensitivity and specificity of serum IGF-1, IGFBP-3 and IGF-1/IGFBP-3 molar ratio, alone and in combinations, for GHD
Methodological detailscross-sectional, observational, 7-year
- Cross-sectional
- Observational
- 7-year
Performance
As reported in the abstract
Diagnostic performance for GHD
| Test or model | Sensitivity | Specificity | Specificity for non-GHD cause of short stature (SS) |
|---|---|---|---|
| Low IGF-1/IGFBP-3 ratio | 87.5% | 83.0% | — not stated in the abstract |
| Low IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ratio | — not stated in the abstract | 97.7% | — not stated in the abstract |
| Normal IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ratio | — not stated in the abstract | — not stated in the abstract | 100.0% |
Sensitivity
Low IGF-1/IGFBP-3 ratio87.5%
Low IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ratio— not stated in the abstract
Normal IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ratio— not stated in the abstract
Specificity
Low IGF-1/IGFBP-3 ratio83.0%
Low IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ratio97.7%
Normal IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ratio— not stated in the abstract
Specificity for non-GHD cause of short stature (SS)
Low IGF-1/IGFBP-3 ratio— not stated in the abstract
Low IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ratio— not stated in the abstract
Normal IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ratio100.0%
— not stated in the abstract
Further findings
Prevalence of GHD
- GHD diagnosed
- 27.2%
Original publication
Serum IGF-1 to IGFBP-3 Molar Ratio: A Promising Diagnostic Tool for Growth Hormone Deficiency in Children. J Clin Endocrinol Metab. Published 17 October 2022. doi:10.
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