Accuracy of Glucagon Testing Across Transition in Young Adults With Childhood-Onset GH Deficiency
Authors' conclusion
A GH peak to GST <5.8 μg/L represents an accurate diagnostic cutoff for young adults with childhood-onset GHD and high pretest probability of permanent GHD.
Study context
- Population
- Young adults with childhood-onset GH deficiency (GHD) at adult height achievement (median age 17.39 years); 44 idiopathic (isolated GHD), 35 moderate organic GHD (0–2 hormone deficiencies), 18 severe organic GHD (≥3 hormone deficiencies)
- Participants
- 97 adults
- Comparison
- GST vs ITT for diagnosis of GHD at adult height achievement
- Outcome
- Accuracy of GST compared to ITT in the definition of GHD
- Follow-up
- Adult height achievement
Performance
As reported in the abstract
Optimal GH peak cutoff to GST (ROC analysis), entire cohort
| Test or model | Value | Sensitivity | Specificity | PPV | NPV | Correctly classified |
|---|---|---|---|---|---|---|
| GST | 7.3 μg/L (95% CI 4.15–8.91) | 95.7% | 88.2% | 88.0% | 95.7% | 91.8% |
GST
Value7.3 μg/L (95% CI 4.15–8.91)
Sensitivity95.7%
Specificity88.2%
PPV88.0%
NPV95.7%
Correctly classified91.8%
Further findings
- Optimal GH peak cutoff to GST, moderate organic GHD
- 5.8 μg/L · 95% CI 3.16–7.39
- Optimal IGF-1 cutoff
- −1.4 SD score · 95% CI −1.94–0.77
GH peak in severe organic GHD (≥3 hormone deficiencies)
- GH peak <5 μg/L at ITT and <5.8 μg/L at GST but 1
Original publication
Accuracy of Glucagon Testing Across Transition in Young Adults With Childhood-Onset GH Deficiency. J Clin Endocrinol Metab. Published 24 June 2024. doi:10.
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