GH Response to Glucagon in Transition: Role of Body Mass Index and Etiology in Childhood-onset GH Deficiency
Authors' conclusion
The GST provides valuable insights into GH deficiency in transitional-age patients with CO-GHD. GH response is primarily influenced by the severity of pituitary dysfunction, with BMI playing a minimal role once adjusted for etiology.
Study context
- Population
- Transitional-age patients with childhood-onset GH deficiency (GHD) (median age 17.39 years) undergoing glucagon stimulation test (GST); childhood cancer survivors 42%
- Participants
- 180 patients
- Exposure
- GH response to GST by etiology and body mass index (BMI) category
- Isolated GHDn = 80
- Organic moderate GHDn = 63
- Organic severe GHDn = 37
- Outcome
- Peak GH response to GST
Main finding
As reported in the abstract
- Significant inverse association with severity of pituitary dysfunction
- P < .001
- Inverse correlation with BMI SD score
- ρ = −0.46, P < .001
Observational data: associations, not effects.
Further findings
Peak GH stratified by etiology or childhood cancer survivors (CCS) status
- GH peaks primarily influenced by hypothalamic-pituitary damage, BMI showing a minimal effect
Original publication
GH Response to Glucagon in Transition: Role of Body Mass Index and Etiology in Childhood-onset GH Deficiency. J Clin Endocrinol Metab. Published 12 January 2026. doi:10.
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