Primary Autoimmune Hypophysitis: Treatment and Predictors of Response to Glucocorticoid in a Single Center in China
Authors' conclusion
GC therapy was effective in achieving both endocrine and radiological remission in patients with PAH. Younger patients were more prone to endocrine response to GC therapy, whereas growth hormone deficiency emerged as an independent unfavorable factor for radiological response to GC treatment.
Study context
- Population
- Patients diagnosed with primary autoimmune hypophysitis (PAH) at a single center in China, December 2009 to October 2022
- Participants
- 77 patients
- Exposure
- Glucocorticoid (GC) therapy vs no GC therapy
- Outcome
- Radiological recovery/improvement
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
P = 0.025
Observational data: associations, not effects.
Further findings
Predictor of endocrine response to GC: age at diagnosis
| OR (CI) | P value | ||
|---|---|---|---|
| Age at diagnosisYounger age an independent favorable factor · logistic regression | 0.897 (0.808–0.995) | P = 0.040 | |
| 0.512Odds ratio (log scale) |
Predictor of radiological response to GC: presence of growth hormone deficiency
| OR (CI) | P value | ||
|---|---|---|---|
| Presence of growth hormone deficiencyIndependent unfavorable factor · logistic regression | 0.094 (0.015–0.580) | P = 0.011 | |
| 0.050.21520Odds ratio (log scale) |
Clinical features of PAH
- Headache (most common symptom)
- 64.9%
- Hypogonadotropic hypogonadism (most common anterior pituitary deficiency)
- 58.9%
- Secondary hypocortisolism
- 57.1%
- Secondary hypothyroidism
- 52.6%
- Vasopressin deficiency
- 61.8%
Original publication
Primary Autoimmune Hypophysitis: Treatment and Predictors of Response to Glucocorticoid in a Single Center in China. Endocr Pract. Published 30 December 2025. doi:10.
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