Low Vasopressin in Myalgic Encephalomyelitise/Chronic Fatigue Syndrome
Authors' conclusion
Our findings suggest that chronic down-regulation of VP mimicking central diabetes insipidus is an important measurable part of the disease mechanism that potentially contributes to criterial symptoms of ME/CFS.
Study context
- Population
- Consecutive patients with myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) per International Consensus Criteria; measurements after 10 h overnight fasting and fluid deprivation111 P-VP + 13 copeptin
- Outcome
- Osmolality and vasopressin after fluid deprivation
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
P-Osm abnormally high (>292 mOsm/kg)
71 of 124
57.3%
U-Osm below reference interval (<750 mOsm/kg)
82 of 124
66.1%
P-VP below level of detection (<1.6 pg/mL)
91 of 111
82.0%
Normal P-VP level compared with P-Osm
11 of 111
9.9%
Observational data: associations, not effects.
Further findings
Brain MRI
- No indication of relevant pathology in hypothalamus or hypophysis
Original publication
Low Vasopressin in Myalgic Encephalomyelitise/Chronic Fatigue Syndrome. Endocr Pract. Published 29 December 2025. doi:10.
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