Psychological profiles of patients with acromegaly: personality traits, quality of life, and clinical correlates
Authors' conclusion
Acromegaly is associated with distinct personality patterns that may influence coping, well-being, and treatment experiences. These findings underscore the potential value of integrating psychosocial assessment and personalized support into the management of acromegaly, and highlight the need for further studies to clarify underlying neurobiological and cultural influences.
Study context
- Population
- Patients with acromegaly, subgrouped by remission status, treatment type and histopathological findings; healthy controls
- Participants
- 77 vs 99
- Exposure
- Patients with acromegaly vs healthy controls
- Acromegalyn = 77
- Healthy controlsn = 99reference
- Outcome
- Temperament and character (Temperament and Character Inventory-Revised (TCI-R))
Main finding
As reported in the abstract
- Patients with acromegaly exhibited higher impulsiveness but lower emotional warmth, persistence and self-directedness vs controls
Observational data: associations, not effects.
Further findings
Associations with clinical variables, anxiety, depression and QoL
- Higher self-acceptance scores associated with remission
- Female patients had significantly lower AcroQoL-Physical scores than male patients
- IGF-1 levels positively correlated with novelty seeking
- QoL negatively correlated with harm avoidance, anxiety and depression; anxiety and depression positively associated with harm avoidance
Original publication
Psychological profiles of patients with acromegaly: personality traits, quality of life, and clinical correlates. Pituitary. Published 26 December 2025. doi:10.
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