Beyond biochemical control: factors associated with quality of life in patients with acromegaly
Authors' conclusion
In this predominantly biochemically controlled cohort, disease-specific QoL was more closely associated with depressive symptom burden and educational status than with the clinical variables examined.
Study context
- Population
- Patients with acromegaly; 46 female, 44 male; 86 in biochemical remission
- Participants
- 90 patients
- Outcome
- Factors associated with total AcroQoL
Main finding
As reported in the abstract
Factors associated with total AcroQoL (hierarchical multivariable linear regression)
Moderate-to-severe depressive symptoms: largest independent association with lower total AcroQoL, B
- 17.56
95% CI - 25.23 to - 9.89p < 0.001
R² from Model 1 to Model 2
0.206 to 0.365
Observational data: associations, not effects.
Further findings
Median quality of life (QoL) and symptom scores
- Median total AcroQoL
- 76.7
- Median Beck Depression Inventory (BDI)
- 10.5
- Median Beck Anxiety Inventory (BAI)
- 9.0
- Median EQ-5D index
- 0.7
- Median EQ-VAS
- 80.0
Sex and education differences
- Female patients had lower total AcroQoL and higher anxiety and depression scores than male patients
- Higher educational status associated with better AcroQoL and lower BDI scores
Original publication
Beyond biochemical control: factors associated with quality of life in patients with acromegaly. Pituitary. Published 20 August 2026. doi:10.
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