The Link Between Acromegaly, Liver Morphology, and MASLD: A Large Cohort Analysis
Authors' conclusion
Hepatic cyst prevalence matched population estimates, whereas imaging-detected MASLD was significantly lower. Cysts associated with older age, renal cysts, and absence of MASLD; MASLD associated inversely with the peri-imaging and longitudinal IGF1 exposure and positively with cholelithiasis.
Study context
- Population
- Acromegaly patients followed at a single tertiary center over four decades282 imaged
- Participants
- 394 patients
- Outcome
- Prevalence of liver findings on imaging
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
- MASLD prevalence
- 31.0%
- Hepatic cyst prevalence
- 15.6%
- Hemangioma prevalence
- 4.3%
- Cholelithiasis prevalence
- 36.8%
- Imaging-detected MASLD vs age- and sex-stratified references (standardized prevalence ratios (SPR))
- 0.56-0.78
Observational data: associations, not effects.
Further findings
Independent predictors of hepatic cyst (multivariable logistic regression)
- Renal cyst, OR
- 2.769
- MASLD (inverse), OR
- 0.231
- Older age borderline significant
Independent predictors of MASLD (multivariable logistic regression)
- Peri-imaging IGF1×ULN, OR per doubling
- 0.74
- Hepatic cyst, OR
- 0.109
- Log2 TWAvg IGF1×ULN, OR
- 0.61
- Cholelithiasis, OR
- 3.158
Original publication
The Link Between Acromegaly, Liver Morphology, and MASLD: A Large Cohort Analysis. Eur J Endocrinol. Published 19 August 2026. doi:10.
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