Changes in multi-modality management of acromegaly in a tertiary centre over 2 decades
Authors' conclusion
The vast majority of patients with acromegaly now have successful disease control with a multimodal approach. They reached biochemical control sooner in the most recent half of the study period. Future work should focus on those patients who are still uncontrolled and on the sequelae of the disease.
Study context
- Population
- Acromegaly patients diagnosed 2000–2020, still followed up in 2020, minimum follow-up 1 year; tertiary centre
- Participants
- 275 patients
- Exposure
- Patients diagnosed after 2010 vs before 2010
- After 2010n = 225
- Before 2010n = 50reference
- Outcome
- Normal IGF-1 levels (with or without treatment)
- Follow-up
- Last
Methodological detailsmonocentric
- Monocentric
Main finding
As reported in the abstract
Patients with normal IGF-1 levels at last follow-up
95%
Observational data: associations, not effects.
Further findings
Transsphenoidal surgery success · tumor characteristics remained the same over time
P < 0.01
Use of RT
P < 0.01
Time from first treatment to biochemical control
P = 0.03
Time from surgery to RT
P = 0.03
Time from first therapy to biochemical control in patients requiring anti-secretory drugs after TSS
P < 0.01
Predictors of remission
- Tumor size, tumor invasiveness, baseline IGF-1 levels and Trouillas classification identified as predictors of remission
Original publication
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