Arginine Vasopressin Deficiency in Children with Craniopharyngioma and Cerebral Germ Cell Tumour: Two Sides of the Same Coin – Clinical and Radiological Features
Authors' conclusion
An early differential diagnosis in children with AVPD and brain tumours is supported by a good understanding of the clinical features and imaging findings. Expert follow-up is necessary.
Study context
- Population
- Children with AVPD and craniopharyngioma or germ cell tumours
- Participants
- 72 children
- Exposure
- Craniopharyngioma (CP) vs GCT
- CPn = 46
- GCTn = 26
- Outcome
- Neuroradiological characteristics and timing of AVPD development
Main finding
As reported in the abstract
- GCT: mean age at AVPD diagnosis
- 11.9 years
- GCT: AVPD at tumour diagnosis
- 18 (69%)
- GCT: AVPD before tumour diagnosis, latency 24.4 months (range 4-48)
- 5 (19.3%)
- GCT: AVPD during follow-up due to recurrence (mean 24 months, range 4-60)
- 3 (11.5%)
- CP: mean age at AVPD diagnosis
- 10.3 years
- CP: AVPD at tumour diagnosis
- 7 (15.2%)
- CP: AVPD shortly after neurosurgery
- 37 (80.5%)
- CP: AVPD 2 and 4 months after surgery
- 2 (4.3%)
- Pituitary stalk thickened in GCT (when measurable)
- 61.5%
Observational data: associations, not effects.
Further findings
Tumour location
- CP: suprasellar / sellar / both
- 63% / 4% / 33%
- GCT: suprasellar / pineal / bifocal
- 65% / 24% / 11%
Presenting features · diagnosis
- GCT: severe endocrinological manifestations
- 18/26
- GCT: headache and vomiting
- 10/26
- GCT: visual impairment
- 5/26
- GCT: behavioural changes with fatigue
- 1/26
- CP: headache and visual abnormalities
- 39/46, 84.8%
- CP: hydrocephalus on initial MRI
- 16/46, 35%
- CP: optic chiasm displacement on initial MRI
- 29/46, 63%
Treatment
- CP: surgery only
- 93%
- GCT: all received radiation therapy in addition to or instead of surgery
Original publication
Arginine Vasopressin Deficiency in Children with Craniopharyngioma and Cerebral Germ Cell Tumour: Two Sides of the Same Coin – Clinical and Radiological Features. Horm Res Paediatr. Published 15 March 2024. doi:10.
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