“Clinical and biochemical distinctions between organic and idiopathic arginine vasopressin deficiency (AVP-D) in children”
Authors' conclusion
Organic AVP-D in children is characterized by a distinct and more severe biochemical phenotype, with profound copeptin suppression and frequent anterior pituitary involvement.
Study context
- Population
- Children diagnosed with AVP-D over a 25-year period; 53 males; mean age 7.9 ± 0.5 years
- Participants
- 105 children
- Exposure
- Organic vs idiopathic AVP-D
- Organicn = 67
- Idiopathicn = 38reference
- Outcome
- Associated anterior pituitary hormone deficiencies
Methodological detailsDiagnosis by water deprivation test and/or arginine-stimulated copeptin; copeptin measured at baseline and after stimulation
- Diagnosis by water deprivation test and/or arginine-stimulated copeptin; copeptin measured at baseline and after stimulation
Main finding
As reported in the abstract
P < 0.0001
Observational data: associations, not effects.
Further findings
Age at diagnosis · younger with idiopathic
P = 0.01
Diagnosis based solely on baseline biochemical parameters
P < 0.0001
Serum sodium, plasma osmolality and copeptin at diagnosis
- Organic AVP-D: significantly higher serum sodium and plasma osmolality, markedly lower baseline and stimulated copeptin
Original publication
“Clinical and biochemical distinctions between organic and idiopathic arginine vasopressin deficiency (AVP-D) in children”. Pituitary. Published 15 April 2026. doi:10.
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