The Dutch prolactinoma cohort studies: cross-sectional analysis of females focusing on the patient's perspective
Authors' conclusion
Females with a prolactinoma were most affected by fatigue and cognitive complaints. Although patients with active disease perceived more burden than patients with controlled disease, symptoms including fatigue, psychological and cognitive complaints were prevalent despite disease control.
Study context
- Population
- Females with prolactinoma in the Dutch PRolaCT or ProlaC study; most treated with dopamine agonists (97.0%)
- Participants
- 450 females
- Exposure
- Active vs controlled prolactinoma
- Activen = 223
- Controlledn = 227reference
- Outcome
- Patient-reported outcome measures (PROMs): symptoms (modified PRO-CTCAE), health-related quality of life (HR-QoL) (SF-36), anxiety and depressive symptoms (Hospital Anxiety and Depression Scale (HADS)), disease burden (LBNQ-Pituitary), by disease activity
Methodological detailsnational cohort, PRolaCT or ProlaC study participants
- National cohort
- PRolaCT or ProlaC study participants
Main finding
As reported in the abstract
PROMs by disease activity
- Fatigue was the most prevalent symptom, followed by concentration problems, in both active and controlled disease
Observational data: associations, not effects.
Further findings
Fatigue (modified PRO-CTCAE, LBNQ-Pituitary)
Concentration problems (modified PRO-CTCAE, LBNQ-Pituitary)
| Outcome | Active | Controlled | P value |
|---|---|---|---|
| HADS-Anxiety | 8.0 ± 4.5 | 6.4 ± 4.5 | P < 0.001 |
| HADS-Depression | 6.4 ± 5.0 | 4.7 ± 4.4 | P < 0.001 |
| Disease burden (LBNQ-Pituitary Total Bother) | 24.4 ± 22.9 | 16.4 ± 17.9 | P < 0.001 |
Original publication
The Dutch prolactinoma cohort studies: cross-sectional analysis of females focusing on the patient's perspective. J Clin Endocrinol Metab. Published 13 August 2026. doi:10.
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