Pituitary & hypothalamus

Prevalence of sick leave before and after pituitary adenoma surgery

Eur J EndocrinolPublished Matched cohort study

Authors' conclusion

Sickness compensation for patients with pituitary adenoma is mainly limited to the surgical period and the months thereafter. Sustained higher levels 1-year post-surgery suggest that work disability remains a long-term issue for a subgroup of patients.

Study context

Population
Working-age patients who had undergone transsphenoidal surgery (TSS) for pituitary adenoma at Sahlgrenska University Hospital, Sweden, and matched general-population controlsmatched controls 1:5
Participants
66 vs 329
Exposure
Patients undergoing TSS for pituitary adenoma vs matched general-population controls
  • Patientsn = 66
  • Controlsn = 329reference
Outcome
Sickness compensation before and after TSS vs the general population
Follow-up
1 year before TSS to up to 2 years after
Methodological detailsregister-based, matched controls (1:5) from the general population, single-centre, Sickness compensation data from national registers
  • Register-based
  • Matched controls (1:5) from the general population
  • Single-centre
  • Sickness compensation data from national registers

Main finding

As reported in the abstract

Sickness compensation
  • Proportion of patients with sickness compensation approximately twice that of controls 1 year prior to TSS
  • Proportion of patients with sickness compensation increased until TSS and decreased thereafter, but did not return to the level 1 year prior to TSS

Observational data: associations, not effects.

Further findings

Factors associated with days to return to work (RTW) after TSS

Prior sickness compensation and Cushing's disease (small subgroup) were predictive of more days to RTW after TSS

Patients without vs with RTW 1-year post-surgery

Patients without RTW reported more fatigue and more often had adrenal insufficiency than patients with RTW

Original publication

Prevalence of sick leave before and after pituitary adenoma surgery. Eur J Endocrinol. Published 13 August 2026. doi:10.1093/ejendo/lvag151

Composed by AI from the published abstract and checked against it. How Briefs are made →

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