Cognitive function and fatigue before and after transsphenoidal surgery in patients with pituitary adenoma: a prospective study
Authors' conclusion
Cognitive function remained largely unchanged from before to 12 months after TSS, while self-reported fatigue improved.
Study context
- Population
- Adults with pituitary adenoma undergoing transsphenoidal surgery (TSS) at Sahlgrenska University Hospital (Gothenburg Pituitary Tumour Study), recruited October 2016–May 2021; 42 non-functioning pituitary adenomas (NFPA), 17 functioning adenoma31 females
- Participants
- 59 adults
- Exposure
- Before vs 12 months after TSS
- Outcome
- Cognitive function (RBANS) and fatigue (MFI-20)
- Follow-up
- Before and 12 months after TSS
Methodological detailsconsecutive inclusion, single-centre, paired before–after comparisons
- Consecutive inclusion
- Single-centre
- Paired before–after comparisons
Main finding
As reported in the abstract
12 months after TSS
- No differences in Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) total or domain indices, except the attention index, which improved
- Total Multidimensional Fatigue Inventory (MFI-20) and all subscale scores improved
Observational data: associations, not effects.
Further findings
Fatigue by adenoma type
- Improvement more pronounced in functioning adenoma, who reported worse fatigue before surgery than NFPA
Individual change in symptom-severity category
- Changed category regarding cognition
- 37%
- Changed category regarding fatigue
- 35%
- Improvements accounted for the majority of these changes
Original publication
Cognitive function and fatigue before and after transsphenoidal surgery in patients with pituitary adenoma: a prospective study. Pituitary. Published 6 May 2025. doi:10.
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