Hypogonadotropic Hypogonadism Before and After Transsphenoidal Surgery for Non‐Functioning Pituitary Adenoma
Authors' conclusion
HH is frequent in men and women with NFPA planned for TSS. Postoperative HPG axis recovery rate is higher in women and is associated with improved QoL.
Study context
- Population
- Consecutive patients with non-functioning pituitary adenoma (non-functioning pituitary adenomas (NFPA)) planned for transsphenoidal surgery (TSS)
- Participants
- 122 consecutive patients
- Exposure
- Hypothalamic-pituitary-gonadal (HPG) axis function before vs 12 months after TSS
- Menn = 73
- Womenn = 49
- Outcome
- Preoperative HH and postoperative recovery
- Follow-up
- Before and 12 months after TSS
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
before and 12 months after TSS
Men with preoperative hypogonadotropic hypogonadism (HH)
50 of 73
68%
Men with HH who recovered
four (8%)
Women of reproductive age with preoperative HH
8 of 13
62%
Women with HH who regained regular menstrual cycles
5
63%
Observational data: associations, not effects.
Further findings
Predictors of persistent HH
- Preoperative central hypothyroidism
- P = 0.046
- Male sex
- P = 0.027
Median total Psychological General Well-Being index (PGWBi) score after surgery · 12 months after TSS
- Increased in both men and women
- P < 0.001
- Among patients with preoperative HH, only women of reproductive age who recovered their HPG axis had improved psychological well-being
Original publication
Hypogonadotropic Hypogonadism Before and After Transsphenoidal Surgery for Non‐Functioning Pituitary Adenoma. Clin Endocrinol (Oxf). Published 6 April 2026. doi:10.
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