Post-operative surveillance for somatotroph, lactotroph and non-functional pituitary adenomas after curative resection: a systematic review
Authors' conclusion
This comprehensive review of the literature quantified the recurrence rates for commonly observed pituitary adenomas after transsphenoidal surgical resection with curative intent. Our findings suggest that surveillance within 1 year may be of low yield. Further clinical trials and cohort studies investigating cost-effectiveness of surveillance schedules and impact on quality of life of patients under surveillance will provide further insight to optimize follow-up.
Study context
- Population
- Patients aged ≥18 years after surgical resection of pituitary adenoma with curative intent; OVID, EMBASE and Cochrane Library searched from inception to March 5, 202077 studies
- Participants
- 3,533 / 1,295 / 1,257
- Comparison
- Recurrence after curative transsphenoidal surgery by adenoma type: Non-functioning pituitary adenomas (NFPA) vs PSPA vs growth-hormone pituitary adenomas (GHPA)
- NFPAn = 3,533
- PSPAn = 1,295
- GHPAn = 1,257
- Outcome
- Pituitary adenoma recurrence rates
- Follow-up
- 1, 5 and 10 years
Methodological details7936 abstracts screened; 812 full-text articles reviewed; 77 included
- 7936 abstracts screened; 812 full-text articles reviewed; 77 included
Pooled result
As reported in the abstract
Recurrence rate · 1 year / 5 years / 10 years NFPA 1%, 17%, 33% · PSPA 6%, 21%, 28% · GHPA 3%, 8%, 13%
1 year
5 years
10 years
Further pooled results
Time to disease recurrence
| Outcome | NFPA | PSPA | GHPA |
|---|---|---|---|
| Recurrence before 1 year · <1 year | 0% | 1-2% | 0% |
Original publication
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