Dissecting the In Vitro Efficacy of Octreotide and Cabergoline in Growth Hormone (GH)- and GH/PRL-Secreting Pituitary Tumors
Authors' conclusion
OCT is 5% to 10% more effective than CAB in vitro. SST1 mRNA expression can represent a reliable marker of GH/PRL co-secreting tumors showing a preferential response to CAB treatment.
Study context
- Population
- Primary cultures of GH- and GH/PRL-secreting pituitary tumors from acromegaly patients referred to the Erasmus Medical Center (Rotterdam, The Netherlands)
- Participants
- 23 tumor cultures
- Comparison
- Octreotide vs cabergoline, 10 nM for 72 hours
- Outcome
- GH concentrations in cell culture media (GH decrease)
- Follow-up
- 72 hours
Methodological detailsin vitro, head-to-head comparison, primary cultures
- In vitro
- Head-to-head comparison
- Primary cultures
Main finding
As reported in the abstract
GH decrease
Octreotide (OCT)
−39.5%
Cabergoline (CAB)
−32.5%
P = 0.079
Further findings
| Outcome | OCT | CAB |
|---|---|---|
| GH decrease in GH/PRL co-secreting tumors · 72 hours | −42.1% | −44.8% |
GH decrease in GH/PRL co-secreting tumors · 72 hours
- Effect of the 2 drugs superimposable
SST1 and D2R expression, GH/PRL co-secreting vs pure GH-secreting tumors
- Higher SST1 expression in GH/PRL co-secreting tumors
- P = 0.020
- Higher D2R expression in GH/PRL co-secreting tumors
- P = 0.026
Cultures with greater response to one drug
- OCT more effective than CAB
- 8/23
- CAB more effective than OCT (CAB+ group)
- 3/23
- Higher SST1 expression in CAB+ tumors vs other groups
- P = 0.034
ROC analysis: discrimination of GH vs GH/PRL co-secretion
- SST1 AUC
- 0.856, P = 0.013
- D2R AUC
- 0.822, P = 0.024
SST1 as predictor of CAB response (≥50% GH reduction)
- AUC
- 0.913, P = 0.006
- Sensitivity
- 80%
- Specificity
- 94%
Original publication
Dissecting the In Vitro Efficacy of Octreotide and Cabergoline in GH- and GH/PRL-Secreting Pituitary Tumors. J Clin Endocrinol Metab. Published 22 November 2022. doi:10.
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