Gigantism: microsurgical treatment by transsphenoidal approach and prognostic factors
Authors' conclusion
Pituitary adenomas that cause gigantism are generally large and invasive, which makes them difficult to cure. High preoperative levels of GH and IGF-1 are also factors that decrease remission.
Study context
- Population
- Patients with gigantism operated by transsphenoidal approach 1982–2004; 4 women, 10 men; age 14–21 years
- Participants
- 14 patients
- Exposure
- Gigantism vs acromegaly
- Gigantismn = 14
- Outcome
- Postoperative hormone levels achieving disease control criteria
Methodological detailssingle-centre, Follow-up with annual check-ups between 3 and 31 years
- Single-centre
- Follow-up with annual check-ups between 3 and 31 years
Main finding
As reported in the abstract
Patients achieving disease control criteria postoperatively
6
42.8%
Observational data: associations, not effects.
Further findings
Invasive tumours on CT/MRI
- Invasive tumours
- 10 (71.4%)
Postoperative CT/MRI
Patients
- No tumour tissue
- 3
- Tumour remains
- 7
- Abnormal images not considered tumour
- 4
Original publication
Gigantism: microsurgical treatment by transsphenoidal approach and prognostic factors. Pituitary. Published 6 November 2022. doi:10.
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