Predictive factors for post-therapeutic biochemical discordance in acromegaly: a monocentric analysis of 156 cases
Authors' conclusion
Overall medication use is the strongest predictor of biochemical discrepancy, with irradiation potentially contributing. No clear distinguishing factors between biochemical discordance and persistent acromegaly were identified, except from disease recurrence. Managing patients with biochemical discrepancy similarly to those with persistent acromegaly may be advisable. Further research is needed to refine treatment strategies.
Study context
- Population
- Patients with growth hormone (GH)-producing pituitary adenomas who underwent transsphenoidal surgery, 1984–2017; median age 48.2 years, 61.5% female; 79.6% macroadenomas, 53.9% invasive
- Participants
- 156 patients
- Exposure
- Predictive factors for post-therapeutic biochemical discordance between GH and IGF-1 after multimodal therapy
- Outcome
- Predictive factors associated with post-therapeutic biochemical discrepancy (GH vs IGF-1)
Methodological detailsmonocentric
- Monocentric
Main finding
As reported in the abstract
Biochemical outcome and predictors of biochemical discrepancy
Biochemical remission achieved
69.9%
Biochemical discrepancy
19.2%
Observational data: associations, not effects.
Further findings
Persistent acromegaly vs biochemical discrepancy
- Disease recurrence was the only distinguishing factor
Original publication
Predictive factors for post-therapeutic biochemical discordance in acromegaly: a monocentric analysis of 156 cases. Pituitary. Published 22 June 2025. doi:10.
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