Usefulness of a clinicopathological classification in predicting treatment-related outcomes and multimodal therapeutic approaches in pituitary adenoma patients: retrospective analysis on a Portuguese cohort of 129 patients from a tertiary pituitary center
Authors' conclusion
This clinicopathological classification appears to be a useful grading system to identify PAs that may be more refractory and more often require complex multimodal and multiple therapeutic approaches. Invasive PAs, especially grade 2b tumors, may be more likely to need complex treatment approach, including radiotherapy, and may display higher rates of active disease at last follow-up, despite receiving higher number of treatments.
Study context
- Population
- Patients with pituitary adenomas operated 2001–2020 at a Portuguese tertiary pituitary centre (84 non-clinically functioning PAs, 32 acromegaly, 9 CD, 2 prolactinomas, 2 thyrotropinomas); 52.7% female, mean age 53.7 ± 15.4 years
- Participants
- 129 patients
- Exposure
- Clinicopathological grades 2b vs 2a vs 1b vs 1a
- 1an = 59
- 1bn = 17
- 2an = 38
- 2bn = 15
- Outcome
- Treatment-related outcomes by grade
- Follow-up
- Mean 93.1 ± 61.8 months
Methodological detailssingle tertiary pituitary centre
- Single tertiary pituitary centre
Main finding
As reported in the abstract
- Persistent tumor remnant within 1 year after operation (2b-2a-1b-1a)
- 93-78-18-30%; p < 0.001
- Active disease at last follow-up (2b-2a-1b-1a)
- 40-27-12-10%; p = 0.004
- Re-operation (2b-2a-1b-1a)
- 27-16-0-5%; p = 0.023
- Irradiation (2b-2a-1b-1a)
- 53-38-12-7%; p < 0.001
- Multimodal treatment (2b-2a-1b-1a)
- 67-49-18-25%; p = 0.003
- Multiple treatment (2b-2a-1b-1a)
- 33-27-6-9%; p = 0.017
- Mean number of treatments (2b-2a-1b-1a)
- 2.6-2.1-1.2-1.4; p < 0.001
Observational data: associations, not effects.
Original publication
Usefulness of a clinicopathological classification in predicting treatment-related outcomes and multimodal therapeutic approaches in pituitary adenoma patients: retrospective analysis on a Portuguese cohort of 129 patients from a tertiary pituitary center. Pituitary. Published 18 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →