3D volume growth rate may open new perspectives for the classification of aggressive pituitary adenomas
Authors' conclusion
PA proliferation may be categorized as: <10%/year: non and/or slowly progressive, 10-49%/year: slowly progressive, 50-79%/year: progressive, ≥80%/year: highly progressive. 3DVGR appears to be a valuable tool to evaluate PA proliferation alongside histology.
Study context
- Population
- Patients with growing or proliferative pituitary adenomas who underwent surgery, with gadolinium-enhanced 3D T1-weighted MRI76 3DVGR measurements
- Participants
- 50 vs 25
- Exposure
- Proliferative vs nonproliferative pituitary adenomas; 3DVGR categories
- Nonproliferative pituitary adenoma (PAs)n = 50reference
- Proliferative PAsn = 25
- Outcome
- 3D volume growth rate (3DVGR), correlated with tumor progression and histopathology
Main finding
As reported in the abstract
Median 3DVGR
P < 0.0001
Observational data: associations, not effects.
Further findings
Median PFS by 3DVGR group
ROC analysis of 3DVGR
- AUC
- 0.992
- P
- P < 0.001
PFS by proliferative status in tumors with 3DVGR <50%/year
- Proliferative status had no significant PFS impact
- P = 0.381
PFS in proliferative tumors, 3DVGR ≥50%/year vs <50%/year
- Worse outcomes with 3DVGR ≥50%/year
- P < 0.001
Multivariate predictors of early progression
- Only 3DVGR ≥50%/year predicted early progression, unlike proliferative status
- P < 0.001
Median PFS: 3DVGR ≥80%/year or 50% ≤3DVGR <80%/year with Ki67 ≥8% (12 PAs) vs others
Months
- Combined criteria (12 PAs)
- 8.5
- Others
- 64
Original publication
3D volume growth rate may open new perspectives for the classification of aggressive pituitary adenomas. J Clin Endocrinol Metab. Published 13 April 2026. doi:10.
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