Copeptin kinetics in healthy aging
Authors' conclusion
Copeptin kinetics are mostly preserved in healthy older adults, yet the ability to suppress copeptin after hydration is diminished.
Study context
- Population
- Healthy older (≥60 years) and younger (18–30 years) adults undergoing copeptin stimulation (3% saline infusion) and suppression (tap water ingestion) tests in randomized order; 50% female in both groups
- Participants
- 16 vs 16
- Comparison
- Healthy older adults vs healthy younger controls
- Older adultsn = 16
- Younger controlsn = 16reference
- Primary endpoint
- Within-subject copeptin range in older adults vs younger controls
Methodological detailscross-over
- Cross-over
Primary result
As reported in the abstract
Within-subject copeptin range
P = 0.867
Further findings
| Outcome | β (pmol·h/L) (95% CI) | P value |
|---|---|---|
| Copeptin response to stimulationComparable between groups | +3.9 (−2.9, +10.7) | P = 0.020 |
| Copeptin decrease during suppressionSmaller decrease in older adults | + .8 (+0.3, +1.3) | P = 0.005 |
Original publication
Copeptin kinetics in healthy aging. J Clin Endocrinol Metab. Published 9 April 2026. doi:10.
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