Association between preoperative MRI radiomic features and methylation-defined phenotypes in non-functioning pituitary adenomas
Authors' conclusion
Preoperative MRI radiomics was associated, at the group level, with a composite methylation-defined risk label previously associated with postoperative regrowth in the same source cohort.
Study context
- Population
- Patients with non-functioning pituitary adenomas (NFPAs) with preoperative gadolinium-enhanced T1-weighted MRI, single centre
- Participants
- 74 patients
- Exposure
- High-risk vs low-risk methylation strata
- Outcome
- Binary discrimination between low-risk (k1/k2) and high-risk (k3/k4/k5) methylation strata by an L1-penalised logistic-regression radiomic model
Methodological detailssingle-centre, nested within a previously published methylation cohort, prespecified model, repeated stratified cross-validation, permutation testing
- Single-centre
- Nested within a previously published methylation cohort
- Prespecified model
- Repeated stratified cross-validation
- Permutation testing
Main finding
As reported in the abstract
Discrimination of high-risk from low-risk tumours by prespecified radiomic model
- Balanced accuracy
- 0.69 (95% CI 0.58-0.80)
- AUC
- 0.73 (95% CI 0.61-0.84)
- 0.632 + AUC
- 0.71
- Permutation p
- p = 0.001
Observational data: associations, not effects.
Further findings
Individual radiomic features
- False-discovery-rate significant features
- 7
- Features surviving Bonferroni correction
- 4
- Predominantly LoG-filtered first-order intensity features
SF1-restricted analysis
- Balanced accuracy
- 0.73
- AUC
- 0.70
- p
- P = 0.008
k3-focused analyses
- k3-focused analyses were not significant
Clinical sex-lineage models
- Clinical sex-lineage models classified at chance
Original publication
Association between preoperative MRI radiomic features and methylation-defined phenotypes in non-functioning pituitary adenomas. Pituitary. Published 31 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →