Cell Lineage-Specific Differences in Clinical Behavior of Non-Functioning Pituitary Adenomas
Authors' conclusion
The use of cell lineage-specific TFs by IHC enables to detect histopathological subtypes of NFPAs with distinct clinical behavior.
Study context
- Population
- Patients with NFPAs positive for one cell lineage-specific TF or negative for all 3, by immunohistochemistry (IHC); cohort studies, Medline, Embase, CENTRAL to July 11, 202327 studies
- Comparison
- NFPA subtypes by cell lineage-specific TF IHC: Null cell adenomas (NCAs), TPIT+, PIT1+ vs SF1+
- Outcome
- Cavernous sinus invasion
Methodological detailsrandom-effects inverse variance models, Mantel-Haenszel prevalence rate ratios, Quality In Prognostic Studies (QUIPS) risk of bias, Two authors independently extracted data and appraised risk of bias (QUIPS)
- Random-effects inverse variance models
- Mantel-Haenszel prevalence rate ratios
- QUIPS risk of bias
- Two authors independently extracted data and appraised risk of bias (QUIPS)
Pooled result
As reported in the abstract
PRR
1.60
95% CI 1.22–2.08P = 0.0036
NCAs vs SF1+ · I2 10%, 95% PrI 1.23-2.06
PRR
1.43
95% CI 1.21–1.70P = 0.0017
TPIT+ vs SF1+ · I2 0%, 95% PrI 1.17-1.76
PRR
1.44
95% CI 1.01–2.06P = 0.0454
NCAs vs PIT1+ · I2 0%, 95% PrI 0.83-2.50
Further pooled results
- Limited number of studies precluded data syntheses of recurrence and radiotherapy
Original publication
Cell Lineage-Specific Differences in Clinical Behavior of Non-Functioning Pituitary Adenomas. J Clin Endocrinol Metab. Published 21 February 2025. doi:10.
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