Sex-dependent increases in oxytocin levels in response to intravenous kisspeptin in humans
Authors' conclusion
Our data support KP as a candidate for a provocative test to identify OXT-D in males.
Study context
- Population
- Healthy adults (50% female)50% female
- Participants
- 12 adults
- Comparison
- Males vs females; OXT after IV kisspeptin (KP) vs baseline
- Outcome
- Change in serum OXT after IV kisspeptin-112-121 (0.24 nmol/kg bolus)
- Follow-up
- 10, 20, 40 and 60 min
Methodological detailssingle-group
- Single-group
Main finding
As reported in the abstract
OXT increase from baseline · 10 min after KP
FDR-P = .004
- OXT increase from baseline, all participants
- 18.8% (FDR-P = .004)
Further findings
Baseline characteristics
- Males and females did not differ significantly in age, BMI or baseline OXT
Original publication
Sex-dependent increases in oxytocin levels in response to intravenous kisspeptin in humans. Eur J Endocrinol. Published 18 February 2025. doi:10.
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