Plasma oxytocin, early predictor of transient postoperative arginine vasopressin deficiency
Authors' conclusion
These results show for the first time that OXT is superior to copeptin for the preoperative prediction of postoperative AVP-D, acting as a preoperative marker of posterior "pituitary reserve".
Study context
- Population
- Consecutive patients undergoing transsphenoidal pituitary surgery (TPS), neurosurgical department of a University Hospital
- Participants
- 74 patients
- Comparison
- Plasma oxytocin (OXT) vs copeptin for prediction of post-TPS arginine vasopressin deficiency (AVP-D)
- Outcome
- Blood copeptin and OXT levels, AVP-D vs normonatremic patients
- Follow-up
- Before, one day after and 3 months after TPS
Methodological detailsconsecutive patients, single-centre
- Consecutive patients
- Single-centre
Performance
As reported in the abstract
Preoperative prediction of post-TPS AVP-D
| Test or model | Value | Sensitivity | Specificity | AUC | P |
|---|---|---|---|---|---|
| OXT | 69 pg/ml | 90% | 66% | 0.76+/−0.06 | p = 0.0089 |
OXT
Value69 pg/ml
Sensitivity90%
Specificity66%
AUC0.76+/−0.06
Pp = 0.0089
Further findings
OXT and copeptin levels at 3 months after TPS
- OXT, but not copeptin, still significantly lower in AVP-D patients
Original publication
Plasma oxytocin, early predictor of transient postoperative arginine vasopressin deficiency. J Clin Endocrinol Metab. Published 8 July 2026. doi:10.
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