Is the diagnosis of Cushing disease moving beyond bilateral inferior petrosal sinus sampling?
An erratum to this article was published (J Clin Endocrinol Metab, 7 Oct 2026 ↗)
Authors' conclusion
Our study demonstrates a decrease over time in the use of BIPSS without loss of efficacy in diagnosis of CD
Study context
- Population
- Consecutive patients with ACTH-dependent CS without evident endocrine tumours, explored 1992–2021 with hormonal testing, pituitary MRI or CT, chest/abdominal CT and bilateral inferior petrosal sinus sampling (BIPSS)single-centre · pituitary MRI 226 · or CT 3 · chest/abdominal CT 114 · BIPSS 113
- Participants
- 229 patients
- Exposure
- Three decades: 1992-2001 vs 2002-2011 vs 2012-2021
- Outcome
- Evolution of BIPSS use and diagnostic outcomes over time
Methodological detailssingle-centre, consecutive patients, intention-to-diagnose analysis
- Single-centre
- Consecutive patients
- Intention-to-diagnose analysis
Main finding
As reported in the abstract
Use of BIPSS
Observational data: associations, not effects.
Further findings
Typical adenoma image at MRI
Confirmed CD (cCD)
Confirmed Cushing's Disease (CD) (confirmed CD (cCD))
- Proportion with cCD remained stable
Final diagnostic classification (intention-to-diagnose, whole cohort)
- Confirmed CD
- 196 (86%)
- Suspected CD
- 24 (10%)
- Confirmed Ectopic ACTH syndrome (EAS)
- 5 (2%)
- Suspected EAS
- 4 (2%)
- Intention-to-diagnose analysis
Original publication
Is the diagnosis of Cushing disease moving beyond bilateral inferior petrosal sinus sampling? J Clin Endocrinol Metab. Published 7 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →