COPeptin Evaluation in arginine vasopressin Deficiency post transsphenoidal surgery (COPED study)
Authors' conclusion
Delta copeptin-the change in copeptin levels from T0 (periextubation) to T1 (2-4 h post-surgery)-predicted AVP-D after TSS.
Study context
- Population
- Patients undergoing transsphenoidal surgery (TSS); copeptin measured preoperatively, periextubation (T0), on first ward arrival (T1), daily until discharge and at week 2
- Participants
- 53 patients
- Comparison
- Arginine vasopressin deficiency (AVP-D) vs non-AVP-D after TSS
- AVP-Dn = 23
- Outcome
- Diagnostic performance of serum copeptin for predicting postoperative AVP-D
Performance
As reported in the abstract
Delta copeptin (% change T0 to T1) for predicting AVP-D
AVP-D
−38%
median
non-AVP-D
+66%
median
P < 0.001
- Delta copeptin AUC for AVP-D (p = 0.001)
- 0.826
- Optimal cutoff
- < −10%
- Sensitivity
- 100%
- Specificity
- 76.2%
Further findings
Copeptin, day 2 · lower in AVP-D
P = 0.021
Copeptin, week 2 · lower in AVP-D
P = 0.021
AVP-D incidence
- Developed AVP-D
- 23 (43.4%)
- Permanent
- 4 (7.5%)
- Transient
- 19 (35.8%)
Week 2 copeptin for predicting permanent AVP-D
- AUC (p = 0.011)
- 0.891
- Optimal cutoff
- < 2.6 pmol/L
- Sensitivity
- 100%
- Specificity
- 66.7%
Original publication
COPeptin Evaluation in arginine vasopressin Deficiency post transsphenoidal surgery (COPED study). Pituitary. Published 29 April 2026. doi:10.
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