Thyrotrophs in PIT1‐lineage Pituitary Neuroendocrine Tumours Without Syndrome of Inappropriate Secretion of Thyrotropin Stimulating Hormone
Authors' conclusion
In the strongly positive group, TSH levels decreased significantly after surgery, whereas no such decrease was observed in the other two groups, suggesting that thyrotrophs in strongly positive PitNETs are TSH-producing, similar to clinically functioning thyrotroph PitNETs.
Study context
- Population
- Patients with PIT1-lineage PitNETs without Secretion of TSH (SITSH), Moriyama Memorial Hospital, April 2018–July 2023
- Participants
- 165 patients
- Exposure
- Strongly positive vs weakly positive vs negative βTSH-immunopositive cell rate in PIT1-lineage PitNETs
- Outcome
- Clinical characteristics and TSH levels by βTSH-positive cell rate
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Age, sex and tumour size did not differ significantly among the groups
- Most weakly positive cases had acromegaly; many strongly positive cases had clinically nonfunctioning tumours
- Preoperative thyroid-stimulating hormone (TSH) slightly higher in strongly positive cases than in the other groups, within normal range postoperatively
- Postoperative TSH significantly lower across all groups
- Degree of postoperative TSH reduction significantly higher in the strongly positive group
Observational data: associations, not effects.
Original publication
Thyrotrophs in PIT1‐lineage Pituitary Neuroendocrine Tumours Without Syndrome of Inappropriate Secretion of Thyrotropin Stimulating Hormone. Clin Endocrinol (Oxf). Published 4 June 2025. doi:10.
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