Diagnosis and Incidence of Congenital Combined Pituitary Hormone Deficiency in Denmark—A National Observational Study
Authors' conclusion
cCPHD had the highest incidence rate and the most hormone deficiencies in those diagnosed at <1 year. The incidence was highest in the 1-17 years age group, underscoring the need for multiple pituitary hormone investigations throughout childhood and adolescence in children with only 1 hormone deficiency.
Study context
- Population
- Patients with congenital combined pituitary hormone deficiency (loss of ≥2 pituitary hormones) diagnosed before age 18 years, identified in Danish national and hospital registries, 1996–2020116 born in Denmark, <18 y
- Participants
- 128 patients
- Outcome
- Incidence of congenital combined pituitary hormone deficiency (cCPHD)
Methodological detailsregistry-based, hospital file review
- Registry-based
- Hospital file review
Main finding
As reported in the abstract
Incidence of cCPHD (born in Denmark, <18 y at diagnosis)
National incidence
10.34 per 100 000 births
95% CI 7.79–13.72
Annual incidence rate
5.74 per million
95% CI 4.33–7.62
Observational data: associations, not effects.
Further findings
| Outcome | <1 year | 1-17 years | P value |
|---|---|---|---|
| Incidence by age at diagnosis (subgroup analysis) | 1.98 per 100 000 births (CI 1.39–2.84) | 7.97 per 100 000 births (CI 5.77–11.00) | |
| Annual incidence rate (CI 13.9-28.4) | 19.8 per million births | — not stated in the abstract | |
| Annual incidence rate (CI 3.39-6.47) | — not stated in the abstract | 4.69 per million births | |
| Number of hormone deficiencies at diagnosisMedian | 3 (IQR 3–4) | 2 (IQR 2–2) | P < 0.0001 |
— not stated in the abstract
Patient characteristics and MRI
- Males
- 88 (68.8%)
- Median (range) age at diagnosis, years
- 6.2 (0.01-19.0)
- Abnormal pituitary MRI findings
- 70.3% (83/118)
Original publication
Diagnosis and Incidence of Congenital Combined Pituitary Hormone Deficiency in Denmark—A National Observational Study. J Clin Endocrinol Metab. Published 12 April 2023. doi:10.
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