Whole-Body and Forearm Muscle Protein Metabolism in Patients With Acromegaly Before and After Treatment
Authors' conclusion
Active acromegaly represents a reversible high flux state in which both whole-body protein breakdown and synthesis are increased, whereas forearm muscle protein kinetics are unaltered. Future studies are needed to decipher the link between protein kinetics and the structure and function of the associated growth hormone-induced increase in lean body mass.
Study context
- Population
- Patients with acromegaly
- Participants
- 18 patients
- Comparison
- Active acromegaly vs after disease control
- Outcome
- Whole-body and forearm muscle protein kinetics after disease control
- Follow-up
- 47 ± 10 weeks after disease control
Methodological detailsbefore-and-after
- Before-and-after
Main finding
As reported in the abstract
47 ± 10 weeks after disease control
- Whole-body phenylalanine breakdown decreased after disease control
- P = .005
- Degradation of phenylalanine to tyrosine decreased
- P = .005
- Whole-body phenylalanine synthesis decreased
- P = .030
- Skeletal muscle protein synthesis tended to decrease
- P = .122
- Muscle protein breakdown unaltered
- P = .437
- Muscle protein loss unaltered
- P = .371
- Unc-51 like autophagy activating kinase 1 phosphorylation increased after disease control
- P = .042
Further findings
- Decrease in lean body mass after disease control
- 7% (P < .000)
- Decrease in lean body mass (LBM)-adjusted energy expenditure
- 14%
Original publication
Whole-Body and Forearm Muscle Protein Metabolism in Patients With Acromegaly Before and After Treatment. J Clin Endocrinol Metab. Published 10 April 2023. doi:10.
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