Increase in intracellular and extracellular myocardial mass in patients with acromegaly: a cardiac magnetic resonance imaging study

Wolf, P; Bouazizi, K; Kachenoura, N; Piedvache, C; Gallo, A; Salenave, S; Maione, L; Young, J; Prigent, M; Lecoq, AL; Kuhn, E; Agostini, H; Trabado, S; Redheuil, A; Chanson, P; Kamenický, P

doi:10.1093/ejendo/lvad105

Pituitary & hypothalamus

Increase in intracellular and extracellular myocardial mass in patients with acromegaly: a cardiac magnetic resonance imaging study

Eur J EndocrinolPublished 7 Aug 2023Cross-sectional study

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Authors' conclusion

Acromegaly results in a disease-specific form of LV hypertrophic remodeling, characterized by an increase in both intra- and extracellular mass. The LV mass index and intracellular mass were decreased by treatment.

Study context

Population: Patients with active acromegaly before and after treatment and controls of comparable age and sex, investigated with cardiac magnetic resonance imaging (MRI)
Participants: 26 vs 31

Exposure: Patients with active acromegaly vs controls of comparable age and sex
Patientsn = 26
Controlsn = 31reference
Outcome: Myocardial T2 relaxation time (myocardial edema)

Methodological detailsprospective

Prospective

Main finding

As reported in the abstract

Myocardial T2 values

T2 values were not different between patients and controls

Observational data: associations, not effects.

Further findings

LV mass index · greater in patients

P < 0.001

Patients58.1 g/m²range 54.7–68.6

Controls46.0 g/m²range 41.3–49.8

Intracellular LV mass index · higher in patients

P < 0.001

Patients43.83 g/m²range 41.0–50.0

Controls34.32 g/m²range 28.9–38.7

Extracellular LV mass index · higher in patients

P < 0.001

Patients15.06 g/m²range 13.5–17.1

Controls11.6 g/m²range 10.8–12.7

EDV index · greater in patients

P = 0.0069

Patients97.3 mL/m²range 88–101.2

Controls81.6 mL/m²range 78.1–96.2

End-diastolic volume (EDV) index

Comparable global contractile function

Correlation of log GH with myocardial mass

R: 0.75
P: P < 0.001

Predictors of left ventricular (LV) mass indexes

Sex, systolic blood pressure (BP) and presence of acromegaly predicted LV mass index
Extracellular LV mass index associated with sex and presence of acromegaly; intracellular with sex, systolic BP and high-density lipoprotein (HDL) cholesterol

Effect of acromegaly treatment

Treatment reduced EDV and total and intracellular LV mass indexes without significantly affecting extracellular mass

Original publication

Increase in intracellular and extracellular myocardial mass in patients with acromegaly: a cardiac magnetic resonance imaging study. Eur J Endocrinol. Published 7 August 2023. doi:10.1093/ejendo/lvad105

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