Sex differences in mortality in patients with acromegaly: a nationwide cohort study in Korea
Authors' conclusion
The risk of mortality and complications in patients with acromegaly compared to age- and sex-matched controls was higher in women than in men.
Study context
- Population
- Patients with acromegaly and matched controls, Korean nationwide claims database 2009–2019matched cohort
- Participants
- 1,884 vs 94,200
- Exposure
- Acromegaly vs age- and sex-matched controls, by sex
- Acromegalyn = 1,884
- Controlsn = 94,200reference
- Outcome
- All-cause mortality, by sex
- Follow-up
- Median 5.51 years
Methodological details1:50 age- and sex-matched controls, Korean nationwide claims database 2009–2019
- 1:50 age- and sex-matched controls
- Korean nationwide claims database 2009–2019
Main finding
As reported in the abstract
All-cause mortality · median 5.51 years
Each group vs controlsHazard ratio (95% CI)
Acromegaly
1.74(1.38–2.19)
HR
- Acromegaly (women)
- 2.17
- Acromegaly (men)
- 1.36
Observational data: associations, not effects.
Further findings
| Outcome | HR |
|---|---|
| All-cause mortality, aged ≥50 yearsWomen with acromegaly aged ≥50 years vs Men with acromegaly aged ≥50 years · significantly higher mortality in women | 1.74 vs 0.96 |
All-cause mortality, treatment subgroup other than surgery alone
- Women had a higher risk of mortality than men (HR 2.82 vs 1.58)
Cause of death
- Most common cause of death was malignancy
Sex differences in mortality after adjustment for Charlson Comorbidity Index (CCI), socioeconomic status (SES), body mass index (BMI), alcohol, smoking, FPG, creatinine, total cholesterol
- Sex differences in mortality remained equal after adjustment
Complications vs age- and sex-matched controls
- Elevated risks of major adverse cardiovascular events (MACE), AF, obstructive sleep apnea (OSA), diabetes mellitus (DM), end-stage renal disease (ESRD), Parkinson's disease (PD), depression and malignancy in acromegaly; higher risk of OSA and DM in women than men
Original publication
Sex differences in mortality in patients with acromegaly: a nationwide cohort study in Korea. Eur J Endocrinol. Published 7 August 2023. doi:10.
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