Risk of depression in patients with acromegaly in Korea (2006-2016): a nationwide population-based study
Main finding · DepressionResult — go to the resultHazard ratio 1.43 95% CI 1.12–1.82Authors' conclusion
Our nationwide study suggests that patients who did not receive treatment for acromegaly have a higher risk of depression compared with controls. The untreated acromegaly patients should be monitored for the development of depression, especially in the early years after diagnosis. These results could serve as a basis for developing screening strategies to mitigate depression in acromegaly patients.
Study context
- Population
- Patients with acromegaly in 2006–2016 from the rare incurable disease registry of the Korean National Health Information Database (NHID)1:5 matched cohort
- Exposure
- Acromegaly vs matched controls without acromegaly
- Outcome
- Risk of depression
Methodological detailsage- and sex-matched 1:5
- Age- and sex-matched 1:5
Main finding
Depression
Hazard ratio
1.43
95% CI 1.12–1.82
Untreatedvs Control
HR 1.43 (95% CI 1.12–1.82)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Depression, first 3 years of observation (multiple Cox regression)Untreatedvs Control | 1.829 (1.305–2.563) | |
| 0.20.5125Hazard ratio (log scale) |
Depression, first 3 years of observation (multiple Cox regression)
- After a time lag of over 3 years, risk of depression in untreated decreased, similar to controls
Original publication
Risk of depression in patients with acromegaly in Korea (2006-2016): a nationwide population-based study. Eur J Endocrinol. Published 30 August 2023. doi:10.
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