High‐Density Lipoprotein Cholesterol Levels and the Risk of Acromegaly: A Nationwide Cohort Study
Main finding · Incident acromegalyResult — go to the resultHazard ratio 1.45 95% CI 1.19–1.78Authors' conclusion
Low HDL-C levels were independently associated with an increased risk of acromegaly.
Study context
- Population
- Adults without pre-existing acromegaly who participated in the national health screening in 2009, National Health Insurance Services, Korea; followed up until 2019
- Participants
- 9,876,423 adults
- Exposure
- Low high-density lipoprotein cholesterol (HDL-C) vs normal HDL-C
- Outcome
- Incident acromegaly
- Follow-up
- Median 9.2 years
Methodological detailsnationwide, population-based
- Nationwide
- Population-based
Main finding
As reported in the abstract
Hazard ratio
1.45
95% CI 1.19–1.78
Low HDL-Cvs Normal HDL-C
HR 1.45 (95% CI 1.19–1.78)
- Developed acromegaly (all participants)
- 459 (4.6 cases per 100,000 people)
Observational data: associations, not effects.
Further findings
Acromegaly risk by HDL-C in four 10 mg/dL categories
| HR (95% CI) | ||
|---|---|---|
| Grade 4 (low HDL-C)Highest risk | 1.78 (1.30–2.43) | |
| 0.512Hazard ratio (log scale) |
- Dose-dependent association with acromegaly risk
Original publication
High‐Density Lipoprotein Cholesterol Levels and the Risk of Acromegaly: A Nationwide Cohort Study. Clin Endocrinol (Oxf). Published 11 May 2025. doi:10.
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