The Role of Late‐Night Salivary Cortisol in the Assessment of Endocrine Remission in Patients With Cushing's Disease After Pituitary Radiotherapy
Authors' conclusion
In patients with CD following RT, LNSC appears to be clinically equivalent to UFC in the assessment of endocrine remission. These patients can be followed with LNSC, which is easier for patients to collect.
Study context
- Population
- Patients aged 16–86 years with Cushing's disease (CD) (persistent/recurrent after pituitary surgery) who underwent pituitary radiotherapy (RT); median age 50 years, 71% female, 63% macroadenomas
- Participants
- 75 patients
- Exposure
- Remission by normal late-night salivary cortisol (LNSC) vs by 24 h urinary free cortisol (UFC)
- Group 1n = 16
- Group 2n = 18reference
- Not in remissionn = 41
- Outcome
- Within-group and between-group changes (group 1 vs group 2) in clinical characteristics, endocrine data and time to remission
Methodological detailsobservational, academic medical centre
- Observational
- Academic medical centre
Main finding
As reported in the abstract
Endocrine remission after RT · median: 56 months
- Entered endocrine remission (overall)
- 34 (45.3%)
Observational data: associations, not effects.
Further findings
| Outcome | Group 1 | Group 2 |
|---|---|---|
| Change in BMI from RT to remission | −3.9 ± 0.7 kg/m² | −5.2 ± 1.9 kg/m² |
| p | p = 0.0001 | p = 0.0123 |
| Change in systolic BP from RT to remission | −7.9 ± 3.9 mmHg | −10.1 ± 4.5 mmHg |
| p | p = 0.03 | p = 0.008 |
Original publication
The Role of Late‐Night Salivary Cortisol in the Assessment of Endocrine Remission in Patients With Cushing's Disease After Pituitary Radiotherapy. Clin Endocrinol (Oxf). Published 11 May 2025. doi:10.
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