Estimation of the biological variation of IGF-I in multimorbid geriatric patients and its clinical implications
Authors' conclusion
The CVi of IGF-I in our cohort differs from that previously described in younger and healthier populations and is therefore crucial for identifying significant changes in this geriatric cohort. The high degree of individuality also supports the application of personalized reference intervals. Our study provides data on the biological variation of IGF-I concentrations in geriatric patients; the calculated RCVs have the potential to refine interpretation.
Study context
- Population
- Multimorbid geriatric outpatients, Ludwig-Maximilians-University Hospital, Munich, with data from the MUnich SArcopenia Registry (MUSAR); mean age 83 years, range 70–97246 serum samples
- Participants
- 89 outpatients
- Outcome
- Intraindividual biological coefficient of variation (CVi) of IGF-I, with Reference Change Values (RCV) and Index of Individuality (II)
Methodological detailsretrospective analysis, mixed-effects model
- Retrospective analysis
- Mixed-effects model
Main finding
As reported in the abstract
Biological variation of IGF-I
- Coefficient of variation (CVi), range
- 13.4 to 15.6%
- CVi, mean
- 14.7%
- Reference Change Values (RCV) for a decrease in IGF-I
- 30.7%
- RCV for an increase in IGF-I
- 44.3%
- Index of Individuality (II)
- 0.44
Observational data: associations, not effects.
Original publication
Estimation of the biological variation of IGF-I in multimorbid geriatric patients and its clinical implications. Pituitary. Published 10 May 2025. doi:10.
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