The somatotroph pituitary gland function in high-aged multimorbid hospitalized patients with IGF-I deficiency
Authors' conclusion
The somatotroph pituitary gland retains its secretory capacity in the advanced aged. Therefore, age does not seem to be the driving pacemaker for the functional decline of the somatotropic axis within the aged population.
Study context
- Population
- High-aged multimorbid hospitalized patients with IGF-I concentrations below two standard deviations of 30-year-old men and women (mean age 82 years), with stable age-related diseases (e.g., coronary artery disease, chronic liver or kidney disease, chronic heart failure) and acute conditions (e.g., urosepsis, endocarditis)11 men · 6 women
- Participants
- 17 participants
- Outcome
- Pituitary GH response (peak GH) to GHRH/arginine stimulation
Main finding
As reported in the abstract
Peak GH concentration after GHRH/arginine stimulation
Average peak growth hormone (GH) concentration after stimulation
14.8 µg/L
range 2.76 to 47.4 µg/L
Pituitary gland adequately stimulated, accounting for gender and BMI
16 out of the 17 patients
Further findings
- Mean BMI
- 26.5 kg/m²
Safety
| Outcome | Values |
|---|---|
| Side effects of GHRH/arginine test | GHRH/arginine test 0 events |
Side effects of GHRH/arginine test
- No patient reported common side effects related to the test
Original publication
The somatotroph pituitary gland function in high-aged multimorbid hospitalized patients with IGF-I deficiency. Pituitary. Published 31 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →