Prevalence and patterns of biochemical discordance in patients with surgically treated acromegaly
Authors' conclusion
The prevalence of biochemical discordance in our cohort was 19.5%. The predominant pattern was elevated IGF-1 levels with a normal nadir GH. The discordant group had higher IGF-1 at diagnosis, suggesting that greater preoperative disease activity may predispose to postoperative biochemical discordance.
Study context
- Population
- Patients with acromegaly after pituitary surgery at Sahlgrenska University Hospital 1994–2019, examined with oral glucose tolerance test (OGTT)
- Participants
- 82 patients
- Exposure
- Postoperative discordant vs concordant growth hormone (GH) and IGF-1
- Discordantn = 16
- Outcome
- Prevalence of postoperative biochemical discordance
- Follow-up
- Postoperative
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Biochemical discordance
Prevalence of biochemical discordance
16
19.5%
Elevated IGF-1 but normal GH among discordant
14 of 16
Observational data: associations, not effects.
Further findings
- IGF-1 at diagnosis: significantly higher with discordance vs controlled concordant group
Baseline variables and treatments
- No differences between discordant and concordant in age, gender, invasive tumour, micro/macro-adenoma, BMI, hypertensive treatment at surgery, postoperative radiotherapy or reoperation
Original publication
Prevalence and patterns of biochemical discordance in patients with surgically treated acromegaly. Pituitary. Published 23 May 2026. doi:10.
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