Determinants of remission and recurrence following transsphenoidal surgery for prolactinoma: a single-center experience
Authors' conclusion
Tumor size, invasiveness, extent of resection, and prolactin levels are key predictors of remission and recurrence. These findings underscore risk-stratified decision-making and long-term surveillance.
Study context
- Population
- Patients undergoing endoscopic transsphenoidal surgery for histologically confirmed prolactinoma, single center, 2010–2022
- Participants
- 52 patients
- Exposure
- Predictors of remission and recurrence after endoscopic transsphenoidal surgery (ETSS) for prolactinoma
- Outcome
- Predictors of acute surgical remission (ASR), long-term remission (LTR) and recurrence
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Remission (ASR, LTR) and recurrence by predictor · median follow-up 5.6 years
Estimate (95% CI)P value
Peak prolactin
HR per ng/mL (recurrence) 1.003(1.001–1.01)
P = 0.01Knosp 2-4
HR (recurrence) 5.64(1.40–22.80)
P = 0.02Cavernous sinus invasion
HR (recurrence) 3.97(1.15–13.64)
P = 0.03GTRvs Subtotal resection
HR (recurrence) 0.19(0.06–0.60)
P = 0.01Postoperative prolactin
HR per ng/mL (recurrence) 1.13(1.04–1.23)
P = 0.01- Median time to recurrence
- 2.6 years
Observational data: associations, not effects.
Original publication
Determinants of remission and recurrence following transsphenoidal surgery for prolactinoma: a single-center experience. Pituitary. Published 23 May 2026. doi:10.
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