Soluble alpha klotho—impact of biological variables and reference intervals for adults
Authors' conclusion
Our findings suggest sαKL is a stable GH-sensitive biomarker that may be less impacted by biological variables compared with IGF-I and IGFBP 3. Our reference intervals will facilitate the potential use of sαKL in GH-related diseases.
Study context
- Population
- Adult population aged 20–89 years; also patients with non-functioning pituitary adenoma (NFPA, n = 18) and prolactinomaprolactinoma 65
- Participants
- 455 vs 435
- Exposure
- Females vs males
- Femalesn = 455
- Malesn = 435reference
- Outcome
- sαKL concentrations: associations with biological variables and reference intervals
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
sαKL concentration
P = 0.01
- Weak negative correlation of sαKL with age; positive correlations with estimated glomerular filtration rate (eGFR) and IGF-I
- P < 0.001 for both
- Correlations with glucose, liver and calcium metabolism and duration of fasting negligible
- P > 0.05 for all
Observational data: associations, not effects.
Further findings
sαKL in pituitary adenoma
- Slightly higher in prolactinoma
- P < 0.05
- Not different in NFPA
Original publication
Soluble alpha klotho—impact of biological variables and reference intervals for adults. Eur J Endocrinol. Published 8 May 2025. doi:10.
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